Main Sector of relevance\IRC classification 3. Biological Sciences

3.22 Veterinary biological therapeutic and preventive medicine in the liquid (Bilavet) and dry (Bilavet-C) preparation forms





Developers’ contact information

State Scientific Institution “The Institute of Microbiology”
220141, Minsk, Academician V.F.Kuprevich St., 2
Теl./Fax: +375 (17) 267-47-66; e-mail: microbio@mbio.bas-net.by; URL: http://mbio.bas-net.by

Kolomiez Emilia Ivanovna
Теl.: +375 (17) 263-51-22; e-mail: microbio@mbio.bas-net.by

Golovneva Natalia Alekseevna
Теl.: +375 (17) 263-51-22; e-mail: biochem_lab@mbio.bas-net.by

Summary

Multicomponent probiotic based on specially selected strains of lactic acid and bifidobacteria which have unique physiological and biochemical properties intended for the prevention and treatment of gastrointestinal disease, normalization of microbiocenosis of the gastrointestinal tract, immunecorrection, stimulation of growth and development of young farm animals and poultry.

Description

Bilavet - probiotic preparation obtained by cultivation of strains of bifido- and lactobacteria which contains live active bacterial cells in amount of no less than 1 × 108 in 1 сm3. Bilavet-C is a dry form of the drug, includes freeze-dried cultures of bifido- and lactic acid bacteria in an amount of no less than 1 × 1010 in 1 g.
The drug is non-pathogenic and nontoxic. Bifido- and lactic acid bacteria of the drug, are characterized by high activity of the growth and acid production, bileproof, acidproof, have high antagonist activity against nominally pathogenic and pathogenic microorganisms of genera Salmonella, Klebsiella, Proteus, Pasteurella, Staphylococcus, Streptococcus, а также E.coli, which cause intestinal diseases of animals, and normalize the intestinal flora, increase nonspecific resistance of the organism. Probiotic improves feed digestibility, contributes to an increase in body weight of animals, activation of redox and metabolic processes, stimulation of the immune system.
Therapeutic and preventive effect of probiotics is due to:
- antagonistic action of bifido- and lactobacteria in relation to pathogenic and nominally pathogenic microorganisms in the gastrointestinal tract;
- the lack of antagonistic effect of bifido- and lactobacteria on other representatives of normal microflora;
- the formation of normal microflora of the gastrointestinal tract;
- the ability of bacteria to synthesize vitamins, amino acids, organic acids, antibiotic substances, enzymes involved in metabolism of carbohydrates and proteins;
- the regulation of immune functions of the microorganism and rise of immune reactivity and natural resistance.

Technology type

Technical advantages and economic benefits

Bilavet (TU BY 100289066.042-2009) or Билавет-С (ТU BY 100289066.083-2010) – a veterinary biological product – is an alternative to feed antibiotics.
Ingredients: contains live active cells (at least 1 × 108/сm3 or 1×1010/g) and metabolites of bifidobacteria and lactic acid bacteria
Intended for the prevention of gastrointestinal diseases of young farm animals and poultry, the restoration of normal microflora of the gastrointestinal tact, activation of redox and metabolic processes in the body, increase of productivity and immunobiological status, stimulation of growth and development of animals for the treatment - against dysbacteriosis, enteritis , diarrhea of bacterial etiology, poisonings.
Preparation form: liquid (Bilavet) with friable sediment or powder (Bilavet-C), freeze-dried cultures of bacteria.
Properties:


Provides:

Terms and conditions of storage:
Bilavet: 6 months at a temperature of 0 ° C - 8 ° C, 1,5 months at a temperature of 8 ° C - 20 ° C;
Bilavet-C: 12 months at a temperature of 0 ° C - 8 ° C.
Advantages: probiotic Bilavet is a non-toxic, environmentally safe preparation, does not adversely affect product quality, as opposed to antibiotics and chemotherapeutic agents the preparation can be used for a long time. Contraindications of Bilavet and Bilavet-C are not available, restrictions on the timing of slaughter of farm animals for meat, the use of milk and other products after treatment are not established. Can be used in combination with substitution therapy preparations, antibacterial drugs.

Technology differentiation and uniqueness

New technology.

Context in which technology was identified

Introduced, industrial production is established, is used in agricultural production complexes and poultry farms of the Republic of Belarus.

Technological keywords

Biotechnology, bacterial preparations, lactobacilli, bifidobacteria, probiotics, therapeutic and preventive effect.

Development Stage

Intellectual property rights

Range of applications

Animal breeding, poultry farming, veterinary medicine, feed production.

Classifier Used at the EU Innovation Relay Centres

Preferable Regions

Practical experience

The technology is introduced and implemented.

Environmental impact

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Type of collaboration sought

Terms and restrictions

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Support provided at transfer of the technology