Contract research organisation providing pre-clinical pharmacological, toxicological and bioanalytical studies to companies, R&D organizations and academic institutions

Summary
The laboratory in a national research institute of the Republic of Belarus provides services for companies and organizations operating in the pharmaceutical, environmental, animal health, food and cosmetics sectors seeking for outsourcing and service agreements for integrated projects or separate activities.

Description
The laboratory has been operating in the Republic of Belarus, Minsk since 2006 in the organization founded in 1974. The experienced R & D team, part of which possessing more than 40 years of academic and research practice, which successfully developed and brought new pharmaceutical drugs to the market, with expertise in preclinical development tests offers the full range of services including pre-clinical drug development, in vitro and in vivo testing, nonclinical safety and efficacy testing, toxicology studies, pharmacokinetics (PK) and ADME studies (Absorption, Distribution, Metabolism & Excretion). The laboratory provides a wide range of tests on pharmaceutical and herbal products, cosmetics, impurities, performs food and chemical testing.[br][/br][br][/br]The portfolio includes, but is not limited to the following fields:[br][/br]Preclinical drug safety studies[br][/br] General toxicity studies: acute toxicity, subacute toxicity, chronic toxicity studies, cumulative toxicity, local irritation. Aquatic toxicology testing is available.[br][/br] Assessment of allergic reactions[br][/br] Immunotoxicity testing[br][/br] Cytogenetic testing: MTT assay in cell cultures (CHO, human and animal embryonic fibroblasts, cultures of human and animal peripheral blood lymphocytes), MTT assay in human cancer cell lines, cell proliferation and cell death assessment via flow cytometry[br][/br] Assessment of mutagenic effects in vitro and in vivo: micronucleus assay, chromosomal aberration assay with different tissues and organs, toxicity tests using microorganisms[br][/br] Reproductive Toxicology assessment (embryotoxicity)[br][/br] Short- and long-term carcinogenicity testing[br][/br] Histological examination, electron microscopy[br][/br]Preclinical drug efficacy testing[br][/br] Cardiovascular studies[br][/br] Hematology testing[br][/br] Biochemistry testing[br][/br] Cancer studies[br][/br] Immunology testing and research[br][/br] Metabolism studies[br][/br] PCR (polymerase chain reaction) testing (Real time PCR, REFL-PCR)[br][/br] Hypotensive, antiischemic (antianginal), antiarrhythmic, cardiotonic, antidiabetic renal protection, hypolipidemic, anti-sclerotic, hypoglycemic, analgesic, anticonvulsant, local anesthetic, locomotor activity, actoprotector, antihypoxant, nootropic, antidepressant, soporific, hepatoprotector effects assessments, assessment of drugs that act on endothelium blood vessels, hemostasis, coordination of movements and muscle tone[br][/br]Pharmacokinetic studies[br][/br] Drug concentration monitoring in blood, tissues and biological fluids[br][/br] Pharmacokinetic parameters calculations[br][/br]Pharmaceutical and physicochemical studies[br][/br] Identification of impurities (heavy metals, sulfated ash, total ash, identification and quantification of residual solvent)[br][/br] Drug authenticity analysis by identifying ions and functional groups[br][/br] Dissolution testing for pharmaceutical dosage forms, comparative dissolution kinetics in different types of environments[br][/br] Dosage form disintegration testing[br][/br] Test for uniformity of mass of single-dose preparations[br][/br] Solubility test[br][/br] Examination of the degree of coloration of liquids[br][/br] Potentiometric measurement of pH[br][/br] Relative density determination[br][/br] Optical rotation determination[br][/br] Melting and boiling point determination[br][/br] Potentiometric titration and titration with the use of an indicator[br][/br] Electrical conductivity measurement[br][/br] Atomic absorption spectroscopy[br][/br] Absorption spectroscopy in the infrared, ultraviolet and visible regions[br][/br] Thin layer chromatography[br][/br] Gas-liquid chromatography[br][/br] High performance liquid chromatography[br][/br] Capillary electrophoresis[br][/br] Inductively coupled plasma mass spectrometry[br][/br]Biological test systems available in the vivarium are outbred rats Wistar, inbred rats (SHR, WKY, WAG/Y, AUG/StоY), hybrid rats, outbred mice ICR, guinea pigs, Californian rabbits, New Zealand white rabbits.[br][/br][br][/br]The company is interested in services and outsourcing agreement. Small and large studies are welcomed. The organization aims to build long term partnerships.

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Technology Type
 Process

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Technology Benefits
The professionals have experience in pharmaceutical, biotech, academia fields, particularly in the area of safety and efficacy testing, DMPK (Drug metabolism and pharmacokinetics), cardiovascular testing[br][/br]Established organization working since 2006[br][/br]Up-to-date equipment[br][/br]The company has worked with national and globally known food and pharmaceutical companies, among which are Swedish, English, Russian organisations, academic institutions, industry[br][/br]The department is accredited according to the ISO/IEC 17025[br][/br]Studies are performed in compliance with Good Laboratory Practice (GLP) regulations[br][/br]Management of studies using a third party contractor is available[br][/br]Competitive rates[br][/br]Can work in strict and fast rate, responsive and easily accessible[br][/br]Consider every project regardless of size[br][/br]

Technological Keywords
In vitro Testing, Trials, Toxicology, Cellular and Molecular Biology, Pharmaceuticals/fine chemicals, Animal health[br][/br]

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Development Stage
 Currently in use/production

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Type of Collaboration Sought
 R&D Contract

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Available Technical Assistance
 Personnel